Endo Presents New Data at the American Podiatric Medical Association Annual Meeting
Results from the Phase 1 clinical study showed improvement in nodule hardness and in patient and physician satisfaction scores. The CCH safety profile in the Phase 1 clinical study was consistent with the known CCH safety profile from other clinical studies. Most adverse events were rated as mild to moderate and there were no treatment-related serious adverse events.
"We're pleased to present new data that explores a potential nonsurgical option in patients with plantar fibromatosis in the future," said
The three new poster presentations are below:
- Tolerability and Safety of Collagenase Clostridium Histolyticum Injection in Participants with Plantar Fibromatosis
- Authors: Richard A. Pollak, DPM;
Christopher J. Anderson, DPM; David Hernandez, MD; Shannon R. Dalton, PhD; Qinfang Xiang, PhD; Saji Vijayan, MBBS; Luis Ortega, MD; Joseph M. Caporusso, DPM
- Efficacy of Collagenase Clostridium Histolyticum Injection, a Potential Nonsurgical Intralesional Treatment Option for Plantar Fibromatosis: A Randomized, Open-Label, Dose-Ranging Study
- Authors: Joseph M. Caporusso, DPM;
Richard A. Pollak, DPM; David Hernandez, MD; Shannon R. Dalton, PhD; Qinfang Xiang, PhD; Saji Vijayan, MBBS; Luis Ortega, MD; Christopher J. Anderson, DPM
- Participant Satisfaction and Investigator Assessment of Collagenase Clostridium Histolyticum Injection as a Nonsurgical Intralesional Treatment Option for Plantar Fibromatosis
- Authors: Christopher J. Anderson, DPM;
Richard A. Pollak, DPM; David Hernandez, MD; Shannon R. Dalton, PhD; Qinfang Xiang, PhD; Saji Vijayan, MBBS; Luis Ortega, MD; Joseph M. Caporusso, DPM
CCH is not approved for use in treating patients with plantar fibromatosis. Endo has completed Phase 2 and anticipates that the pivotal Phase 3 program will begin later this year.
About Plantar Fibromatosis
Plantar fibromatosis (PFI) or Ledderhose disease, sometimes termed "Dupuytren's disease of the foot," is a hyperproliferative fibrous tissue disorder resulting in the formation of nodules along the plantar fascia, the thick connective tissue that supports the arch of the foot, which is often painful. There is no cure for PFI. Symptom management options include custom insoles, topical treatments, over-the-counter pain and anti-inflammatory medications, radiation therapy and steroid injections, and ultimately, surgery may be required to remove the nodules.
Endo (OTC: ENDPQ) is a specialty pharmaceutical company committed to helping everyone we serve live their best life through the delivery of quality, life-enhancing therapies. Our decades of proven success come from passionate team members around the globe collaborating to bring treatments forward. Together, we boldly transform insights into treatments benefiting those who need them, when they need them. Learn more at www.endo.com or connect with us on LinkedIn.
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